Marked mitochondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow.

@article{Shin2004MarkedMD,
  title={Marked mitochondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow.},
  author={Myung Geun Shin and Sachiko Kajigaya and J. Philip McCoy and Barbara Chernov Levin and Neal S. Young},
  journal={Blood},
  year={2004},
  volume={103 2},
  pages={
          553-61
        }
}
Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in postmitotic tissues but have been postulated to be diluted and lost in continually proliferating tissues such as bone marrow (BM). Having observed marked sequence variation among healthy adult individuals' total BM cell mtDNA, we undertook analysis of the mtDNA control region in a total of 611 individual CD34+ clones from 6 adult BM donors and comparison of these results with the sequences from 580 CD34+ clones from 5 umbilical… CONTINUE READING

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