Marked increase of serum hepatitis C virus (HCV) RNA titer during treatment with high-dose prednisolone in a case of polymyositis

  title={Marked increase of serum hepatitis C virus (HCV) RNA titer during treatment with high-dose prednisolone in a case of polymyositis},
  author={Takashi Kato and Takahiro Okai and Takuya Shiroma and Junko Fukuda and Ryuichi Yokohari and Masao Tadokoro},
  journal={Clinical Rheumatology},
A 70-year-old Japanese woman with hepatitis C virus (HCV) infection was diagnosed with polymyositis and treated with high-dose prednisolone (PSL). The serum alanine aminotransferase (ALT) level increased from 78 to 345 U/l 1 week after initiating treatment, although the polymyositis settled promptly. Furthermore, the serum HCV RNA level increased markedly from 110 to 850 kIU/ml 3 weeks after starting treatment. Previously, the patient had suffered an occlusion of the left branch of the retinal… 
Neuromuscular Diseases Associated With Chronic Hepatitis C Virus Infection
  • J. Stübgen
  • Medicine, Biology
    Journal of clinical neuromuscular disease
  • 2011
The therapeutic approach to HCV-associated autoimmune disorders entails eradication of HCV with one of the recombinant interferon-alpha preparations with or without additional immunosuppressive drugs.
A case of acute exacerbation of chronic hepatitis C during the course of adrenal Cushing's syndrome
A 50‐year‐old woman with adrenal Cushing's syndrome and chronic hepatitis C developed an acute exacerbation of Chronic hepatitis C before adrenectomy after administration of glecaprevir/pibrentasvir was started and a rapid virological response also was achieved.
Damage and inflammation in muscular dystrophy: potential implications and relationships with autoimmune myositis
An updated evaluation of the role of inflammation in muscular dystrophy is provided, and findings which suggest that non-immunological factors promote idiopathic inflammatory myopathies are presented, which indicate that immune-targeted interventions may provide useful approaches to treat muscular Dystrophy.


Hepatitis C viremia in chronic liver disease: Relationship to interferon‐α or corticosteroid treatment
A low pretreatment value of viremia could identify patients with chronic hepatitis who will derive long‐term benefit from interferon, and polymerase chain reaction being more sensitive than the branched‐DNA test.
A longitudinal analysis of hepatitis C virus replication following liver transplantation.
BACKGROUND & AIMS The pathogenesis of graft injury in liver transplant recipients with recurrent hepatitis C virus (HCV) infection remains poorly understood. In this study, the relationship between
Effect of tumour necrosis factor α antagonists on serum transaminases and viraemia in patients with rheumatoid arthritis and chronic hepatitis C infection
Findings suggest that TNFα antagonists merit further study for the treatment of RA in HCV infected patients, and larger and longer term studies are still needed.
Long-Term Treatment of Chronic Hepatitis C with Glycyrrhizin [Stronger Neo-Minophagen C (SNMC)] for Preventing Liver Cirrhosis and Hepatocellular Carcinoma
Results indicate that a long-term treatment with Stronger Neo-Minophagen C prevents the development of HCC in the patients with chronic hepatitis.
Development of fulminant hepatitis B (precore variant mutant type) after the discontinuation of low-dose methotrexate therapy in a rheumatoid arthritis patient.
A 75-year-old female rheumatoid arthritis patient who was positive for hepatitis B surface antigen and for antibodies to hepatitis Be antigen showed liver dysfunction, and therefore methotrexate (MTX) therapy was discontinued, and she developed fulminant hepatitis with elevated levels of hepatitis B virus (HBV)/DNA polymerase and subsequently died.
Long-term impact of renal transplantation on liver fibrosis during hepatitis C virus infection.
It is suggested that liver fibrosis progression is low in most HCV-infected renal transplant recipients with moderate liver disease at baseline, compared with controls without renal disease and untreated for HCV.
Hepatitis C virus infection.
The institution of blood-screening measures in developed countries has decreased the risk of transfusion-associated hepatitis to a negligible level, but new cases continue to occur mainly as a result of injection-drug use and, to a lesser degree, through other means of percutaneous or mucous-membrane exposure.
Induction of tumour necrosis factor (TNF) receptor type p55 and p75 in patients with chronic hepatitis C virus (HCV) infection
It is demonstrated that TNF‐α and TNFRs are enhanced in chronic HCV infection and reflect histological activity of the disease, which might modify host response and potentially contribute to liver damage in chronicHCV infection.
Hepatitis C Virus Core Protein Binds to the Cytoplasmic Domain of Tumor Necrosis Factor (TNF) Receptor 1 and Enhances TNF-Induced Apoptosis
The results together suggest that the core protein can promote cell death during HCV infection via TNF signaling pathways possibly as a result of its interaction with the cytoplasmic tail of TNFR 1.