Marked improvement of glucose homeostasis in diabetic ob/ob mice given oral vanadate.

@article{Brichard1990MarkedIO,
  title={Marked improvement of glucose homeostasis in diabetic ob/ob mice given oral vanadate.},
  author={Sonia M. Brichard and Clifford J Bailey and Jean-Claude Henquin},
  journal={Diabetes},
  year={1990},
  volume={39 11},
  pages={1326-32}
}
The trace element vanadium exerts insulinlike effects in vitro and decreases hyperglycemia in insulin-deficient animals. This study examined whether vanadate can improve glucose homeostasis in genetically obese hyperglycemic insulin-resistant ob/ob mice, which present metabolic abnormalities similar to those of human non-insulin-dependent diabetes. Sodium orthovanadate (0.3 mg/ml) was administered for 7 wk in H2O. Vanadate treatment induced a fall in fed and fasted plasma glucose and insulin… CONTINUE READING
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