Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARγ‐specific retinoid, but not by ER35794, an RXR‐selective agonist

@article{Sakuta2006MarkedII,
  title={Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARγ‐specific retinoid, but not by ER35794, an RXR‐selective agonist},
  author={T. Sakuta and T. Kanayama},
  journal={International Journal of Dermatology},
  year={2006},
  volume={45}
}
Background  Photoaging (premature skin aging) results largely from repeated exposure of the skin to ultraviolet (UV) radiation from the sun. Topical all‐trans retinoic acid (RA), the only agent that has been approved for the treatment of photoaging, has been shown to reverse this process. In this study, we evaluated the pharmacologic effects of novel synthetic retinoids, ER36009 and ER35794, on murine wrinkles induced by UVB. ER36009 is a specific agonist of retinoic acid receptor (RAR)γ, the… Expand
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