Marked enhancement of the immune response to BioThrax® (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers.

@article{Rynkiewicz2011MarkedEO,
  title={Marked enhancement of the immune response to BioThrax® (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers.},
  author={Dianna Rynkiewicz and Melinda McNeal Rathkopf and Iain Sim and A Thomas Waytes and Robert J Hopkins and Lallan Giri and Deborah DeMuria and Janet Ransom and James J. Quinn and Gary S Nabors and Carl Nielsen},
  journal={Vaccine},
  year={2011},
  volume={29 37},
  pages={6313-20}
}
Immunization with BioThrax(®) (Anthrax Vaccine Adsorbed) is a safe and effective means of preventing anthrax. Animal studies have demonstrated that the addition of CpG DNA adjuvants to BioThrax can markedly increase the immunogenicity of the vaccine, increasing both serum anti-protective antigen (PA) antibody and anthrax toxin-neutralizing antibody (TNA) concentrations. The immune response to CpG-adjuvanted BioThrax in animals was not only stronger, but was also more rapid and led to higher… CONTINUE READING

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