Marked enhancement by rifampicin and lack of effect of isoniazid on the elimination of quinine in man.

@article{Wanwimolruk1995MarkedEB,
  title={Marked enhancement by rifampicin and lack of effect of isoniazid on the elimination of quinine in man.},
  author={Sompon Wanwimolruk and W Kang and Philippe Coville and S Viriyayudhakorn and Supachai Thitiarchakul},
  journal={British journal of clinical pharmacology},
  year={1995},
  volume={40 1},
  pages={87-91}
}
The effect of rifampicin and isoniazid pretreatment on the pharmacokinetics of quinine after a single oral dose (600 mg quinine sulphate) was studied in nine healthy young Thai male volunteers using a three-way randomized crossover design. Subjects were studied over three 2 day periods, during which they received no pretreatment, or pretreatment with daily 600 mg p.o. rifampicin for 2 weeks, or isoniazid 300 mg p.o. daily for 1 week, prior to quinine administration. The mean (+/- s.d… CONTINUE READING

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