Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.

@article{Becker2007MarkedEI,
  title={Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.},
  author={Achim Becker and Sandra Vezmar and Michael Linnebank and Hendrik Pels and Udo Bode and Uwe Schlegel and Ulrich Jaehde},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2007},
  volume={45 9},
  pages={504-15}
}
OBJECTIVE Interference of methotrexate (MTX) with the metabolism of homocysteine may contribute to MTX neurotoxicity. In this pilot study we measured the concentration of homocysteine and related metabolites in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma undergoing intensive treatment with MTX. MATERIAL AND METHODS CSF samples from lymphoma patients (n = 4) were drawn at the end of high-dose MTX infusions (3-5 g/m2/24 h, HDMTX) and one day after… CONTINUE READING