Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.

@article{Becker2007MarkedEI,
  title={Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.},
  author={Achim Becker and Sandra Vezmar and Michael Linnebank and Hendrik Pels and U. Bode and Udo Schlegel and Ulrich Jaehde},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2007},
  volume={45 9},
  pages={
          504-15
        }
}
  • Achim Becker, Sandra Vezmar, +4 authors Ulrich Jaehde
  • Published in
    International journal of…
    2007
  • Medicine
  • OBJECTIVE Interference of methotrexate (MTX) with the metabolism of homocysteine may contribute to MTX neurotoxicity. In this pilot study we measured the concentration of homocysteine and related metabolites in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma undergoing intensive treatment with MTX. MATERIAL AND METHODS CSF samples from lymphoma patients (n = 4) were drawn at the end of high-dose MTX infusions (3-5 g/m2/24 h, HDMTX) and one day after… CONTINUE READING

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 16 CITATIONS

    Cardiovascular actions of l-cysteine and l-cysteine sulfinic acid in the nucleus tractus solitarius of the rat

    VIEW 2 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED