Marked differences between prone and supine sheep in effect of PEEP on perfusion distribution in zone II lung.

@article{Walther2005MarkedDB,
  title={Marked differences between prone and supine sheep in effect of PEEP on perfusion distribution in zone II lung.},
  author={Sten M. Walther and Mats J. Johansson and Torun Flateb\o and Anne Nicolaysen and Gunnar Nicolaysen},
  journal={Journal of applied physiology},
  year={2005},
  volume={99 3},
  pages={909-14}
}
The classic four-zone model of lung blood flow distribution has been questioned. We asked whether the effect of positive end-expiratory pressure (PEEP) is different between the prone and supine position for lung tissue in the same zonal condition. Anesthetized and mechanically ventilated prone (n = 6) and supine (n = 5) sheep were studied at 0, 10, and 20 cm H2O PEEP. Perfusion was measured with intravenous infusion of radiolabeled 15-microm microspheres. The right lung was dried at total lung… CONTINUE READING