Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.

@article{Balzarini2005MarkedDO,
  title={Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis.},
  author={Jan Balzarini and Kristel van Laethem and Sigrid Hatse and Matheus Froeyen and Els J. M. van Damme and Anders Bolmstedt and Willy J. Peumans and Erik de Clercq and Dominique Schols},
  journal={Molecular pharmacology},
  year={2005},
  volume={67 5},
  pages={1556-65}
}
The plant lectins from Hippeastrum hybrid (HHA) and Galanthus nivalis (GNA) are 50,000-D tetramers showing specificity for alpha-(1,3) and/or alpha-(1,6)-mannose oligomers. They inhibit HIV-1 infection at a 50% effective concentration of 0.2 to 0.3 microg/ml. Escalating HHA or GNA concentrations (up to 500 microg/ml) led to the isolation of three HIV-1(III(B)) strains in CEM T cell cultures that were highly resistant to HHA and GNA, several other related mannose-specific plant lectins, and the… CONTINUE READING

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