Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats.

@article{Yang2006MarkedDO,
  title={Marked decrease of cyclosporin bioavailability caused by coadministration of ginkgo and onion in rats.},
  author={C. Y. Yang and P. L. Chao and Y. Hou and S. Tsai and K. C. Wen and S. L. Hsiu},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2006},
  volume={44 9},
  pages={
          1572-8
        }
}
  • C. Y. Yang, P. L. Chao, +3 authors S. L. Hsiu
  • Published 2006
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • Quercetin was reported to modulate CYP isoenzymes and P-glycoprotein (Pgp), a drug efflux transporter. Our previous study reported that quercetin significantly decreased the bioavailability of cyclosporin, a substrate for CYP3A4 and Pgp, in rats and pigs. Ginkgo and onion contain quercetin and its glycosides as St. John's Wort. The coadministration of cyclosporin with ginkgo or onion may be subject to clinically relevant interactions as St. John's Wort. Therefore, this study aimed to… CONTINUE READING

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