Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice.

@article{Krall2008MarkedDO,
  title={Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice.},
  author={Catherine M. Krall and J Barrett Richards and Richard A. Rabin and Jerrold C. Winter},
  journal={Pharmacology, biochemistry, and behavior},
  year={2008},
  volume={88 3},
  pages={349-57}
}
RATIONALE Based upon extensive studies in the rat, it has been suggested that stimulus control by LSD is mediated by 5-HT2A receptors, with serotonergic receptors of the 5-HT1A and 5-HT2C subtypes playing modulatory roles. In genetically modified mice lacking the serotonin transporter (SERT), 5-HT2A receptor density is decreased and, at a functional level, the head-twitch response following the administration of DOI, an index of activation of 5-HT2A receptors, is reduced. Taken together, these… CONTINUE READING

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