Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis

@inproceedings{Fogarty2016MarkedCI,
  title={Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1G93A mouse model of amyotrophic lateral sclerosis},
  author={Matthew J Fogarty and Erica W. H. Mu and Peter G. Noakes and Nickolas A. Lavidis and Mark C Bellingham},
  booktitle={Acta neuropathologica communications},
  year={2016}
}
Amyotrophic lateral sclerosis (ALS) is characterised by the death of upper (corticospinal) and lower motor neurons (MNs) with progressive muscle weakness. This incurable disease is clinically heterogeneous and its aetiology remains unknown. Increased excitability of corticospinal MNs has been observed prior to symptoms in human and rodent studies. Increased excitability has been correlated with structural changes in neuronal dendritic arbors and spines for decades. Here, using a modified Golgi… CONTINUE READING
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References

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Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G⁹³A transgenic ALS mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2011
View 10 Excerpts
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The cognitive profile of ALS: a systematic review and meta-analysis update.

Journal of neurology, neurosurgery, and psychiatry • 2016
View 1 Excerpt

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