Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4-/- mice

@article{Chen2007MarkedAO,
  title={Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4-/- mice},
  author={Xiaojie Chen and Nicole Alessandri-Haber and Jon D Levine},
  journal={Molecular Pain},
  year={2007},
  volume={3},
  pages={31 - 31}
}
Inflammatory mediators can directly sensitize primary afferent nociceptors to mechanical and osmotic stimuli. Sensitized nociceptors have a lowered threshold of activation and increased spontaneous activity, which result in symptoms of hyperalgesia and pain, respectively. The transient receptor potential vanilloid 4 (TRPV4) ligand-gated ion channel has been implicated in the hyperalgesia for mechanical and osmotic stimuli associated with inflammatory states. To investigate whether TRPV4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Cutaneous irritancy of water.

Reviews on environmental health • 2014
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 32 references

Abnormal osmotic regulation in trpv4-/- mice.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 4 Excerpts
Highly Influenced

TRPV 4 - mediated regulation of epithelial permeabil

B Reiter, R Kraft, +3 authors M Fromm
Faseb J • 2006

TRPV4-mediated regulation of epithelial permeability.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2006
View 1 Excerpt

- related behavior induced by mild hypertonic stimuli in the presence of inflammatory media

N Alessandri-Haber, OA Dina, EK Joseph, D Reichling, JD Levine
2005

Similar Papers

Loading similar papers…