Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives.

@article{Legler1986MarkedAI,
  title={Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives.},
  author={U. F. Legler and Leslie Z Benet},
  journal={Clinical pharmacology and therapeutics},
  year={1986},
  volume={39 4},
  pages={425-9}
}
Six healthy women chronically (greater than 6 months) using oral contraceptives were age- and weight-matched with female controls. Each subject received prednisolone, 0.53 and 0.14 mg/kg iv. In the subjects taking oral contraceptives there were significant decreases in total clearance, unbound clearance, and volume of distribution at steady state for total… CONTINUE READING