Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.

@article{Shafaati2011MarkedAO,
  title={Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.},
  author={Marjan Shafaati and Amelia Marutle and Hanna Pettersson and Anita L{\"o}vgren-Sandblom and Maria Olin and Irina Pikuleva and Bengt Winblad and A. Nordberg and Ingemar Bj{\"o}rkhem},
  journal={Journal of lipid research},
  year={2011},
  volume={52 5},
  pages={1004-10}
}
There is a significant flux of the neurotoxic oxysterol 27-hydroxycholesterol (27OHC) from the circulation across the blood-brain barrier. Because there is a correlation between 27OHC and cholesterol in the circulation and lipoprotein-bound cholesterol does not pass the blood-brain barrier, we have suggested that 27OHC may mediate the effects of hypercholesterolemia on the brain. We previously demonstrated a modest accumulation of 27OHC in brains of patients with sporadic Alzheimer's disease… CONTINUE READING

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Sequence alteration within CYP 7 B 1 implicate defective cholesterol homeostasis in motor - neuron degeneration

R. Schule, T. Siddique, +6 authors I. Björkhem
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