Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome

  title={Marked Suppression of Ghrelin Concentration by Insulin in Prader-Willi Syndrome},
  author={K. Paik and Moon-Kyu Lee and Dong-kyu Jin and Hahn Wook Kang and Kyung Han Lee and An Hee Kim and Cheol Keun Kim and Ji Eun Lee and Yoo Joung Oh and Seonwoo Kim and Sun Joo Han and E. K. Kwon and Yon Ho Choe},
  booktitle={Journal of Korean medical science},
The plasma ghrelin has been reported to be elevated in Prader-Willi syndrome (PWS) and modulated by insulin. It was hypothesized that insulin might have a more pronounced effect on reducing plasma ghrelin in PWS patients, which would influence appetite. This study investigated the degree of ghrelin suppression using an euglycemic hyperinsulinemic clamp in children with PWS (n=6) and normal children (n=6). After a 90-min infusion of insulin, the plasma ghrelin level decreased from a basal value… CONTINUE READING

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Plasma ghrelin levels and its relationship with obesity in obese children

DS Jo, JU Lee, +3 authors DY. Lee
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Ghrelin in the Prader-Willi Syndrome

DK Jin
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