Marked Prevention of Ischemic Brain Injury by Neu2000, an NMDA Antagonist and Antioxidant Derived from Aspirin and Sulfasalazine

@article{Gwag2007MarkedPO,
  title={Marked Prevention of Ischemic Brain Injury by Neu2000, an NMDA Antagonist and Antioxidant Derived from Aspirin and Sulfasalazine},
  author={Byoung Joo Gwag and Young Ae Lee and Sun Young Ko and Moon Jung Lee and Doo Soon Im and Bok Sun Yun and Hyang Ran Lim and Sun Mi Park and Han Yeol Byun and Sun Son and Hye-jin Kwon and Ji Yoon Lee and Jaeyoung Cho and Seok Joon Won and Kee-Won Kim and Young Min Ahn and Ho Sang Moon and Hae Un Lee and Sung‐Hwa Yoon and Jihyun Noh and Jun-mo Chung and Sung Ig Cho},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={2007},
  volume={27},
  pages={1142 - 1151}
}
Excitotoxicity and oxidative stress mediate neuronal death after hypoxic—ischemic brain injury. We examined the possibility that targeting both N-methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity and oxidative stress would result in enhanced neuroprotection against hypoxic—ischemia. 2-Hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid (Neu2000) was derived from aspirin and sulfasalazine to prevent both NMDA neurotoxicity and oxidative stress. In cortical cell… 
Attenuated effects of Neu2000 on hypoxia-induced synaptic activities in a rat hippocampus
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TLDR
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TLDR
The results demonstrated that NsTyr could protect cells against AIF-mediated caspase-independent cell death induced by glutamate, which may be due to the blockage of Bid-mediated mitochondrial damage via reducing LOX 12/15 activity and ROS accumulation.
Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis
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Evidence is provided that jointly targeting oxidative stress and Fas-mediated apoptosis can prevent neuronal loss and motor dysfunction in ALS.
Concurrent Administration of Neu 2000 and Lithium Produces Marked Improvement of Motor Neuron Survival , Motor Function , and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis
TLDR
Evidence is provided that jointly targeting oxidative stress and Fas-mediated apoptosis can prevent neuronal loss and motor dysfunction in ALS.
Antioxidant properties of Neu2000 on mitochondrial free radicals and oxidative damage.
Blood-derived iron mediates free radical production and neuronal death in the hippocampal CA1 area following transient forebrain ischemia in rat
TLDR
The present findings suggest that excessive iron transported from blood mediates slowly evolving oxidative stress and neuronal death in CA1 after TFI, and that targeting iron-mediated oxidative stress holds extended therapeutic time window against an ischemic event.
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