Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis

@article{Balzarini2005MarkedDO,
  title={Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis},
  author={J. Balzarini and K. van Laethem and S. Hatse and M. Froeyen and E. V. Van Damme and A. Bolmstedt and W. Peumans and E. de Clercq and D. Schols},
  journal={Molecular Pharmacology},
  year={2005},
  volume={67},
  pages={1556 - 1565}
}
  • J. Balzarini, K. van Laethem, +6 authors D. Schols
  • Published 2005
  • Medicine, Biology
  • Molecular Pharmacology
  • The plant lectins from Hippeastrum hybrid (HHA) and Galanthus nivalis (GNA) are 50,000-D tetramers showing specificity for α-(1,3) and/or α-(1,6)-mannose oligomers. They inhibit HIV-1 infection at a 50% effective concentration of 0.2 to 0.3 μg/ml. Escalating HHA or GNA concentrations (up to 500 μg/ml) led to the isolation of three HIV-1(IIIB) strains in CEM T cell cultures that were highly resistant to HHA and GNA, several other related mannose-specific plant lectins, and the monoclonal… CONTINUE READING
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