Marked Cortisol Production by Intracrine ACTH in GIP-Treated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced

Abstract

The ectopic expression of the glucose-dependent insulinotropic polypeptide receptor (GIPR) in the human adrenal gland causes significant hypercortisolemia after ingestion of each meal and leads to Cushing's syndrome, implying that human GIPR activation is capable of robustly activating adrenal glucocorticoid secretion. In this study, we transiently… (More)
DOI: 10.1371/journal.pone.0110543

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Cite this paper

@inproceedings{Fujii2014MarkedCP, title={Marked Cortisol Production by Intracrine ACTH in GIP-Treated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced}, author={Hiroko Fujii and Mimi Tamamori-Adachi and Kousuke Uchida and Takao Susa and Takashi Nakakura and Haruo Hagiwara and Masayoshi Iizuka and Hiroko Okinaga and Yuji Tanaka and T. Okazaki and Carlos M. Isales}, booktitle={PloS one}, year={2014} }