Mariner is defective in myosin VIIA: a zebrafish model for human hereditary deafness.

@article{Ernest2000MarinerID,
  title={Mariner is defective in myosin VIIA: a zebrafish model for human hereditary deafness.},
  author={S Ernest and G J Rauch and Pascal Haffter and Robert Geisler and Christine Petit and Teresa Nicolson},
  journal={Human molecular genetics},
  year={2000},
  volume={9 14},
  pages={2189-96}
}
The zebrafish (Danio rerio) possesses two mechanosensory organs believed to be homologous to each other: the inner ear, which is responsible for the senses of audition and equilibrium, and the lateral line organ, which is involved in the detection of water movements. Eight zebrafish circler or auditory/vestibular mutants appear to have defects specific to sensory hair cell function. The circler genes may therefore encode components of the mechanotransduction apparatus and/or be the orthologous… CONTINUE READING