Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species

@article{Arai2012MarinederivedFS,
  title={Marine-derived fungal sesterterpenes, ophiobolins, inhibit biofilm formation of Mycobacterium species},
  author={Masayoshi Arai and Hiroki Niikawa and Motomasa Kobayashi},
  journal={Journal of Natural Medicines},
  year={2012},
  volume={67},
  pages={271-275}
}
Biofilm formation in pathogenic bacteria defends them from antibiotics and the host’s immune system. In the course of our search for new inhibitors of biofilm formation in Mycobacterium species, we isolated the sesterterpenes ophiobolin K (1), 6-epi-ophiobolin K (2), and 6-epi-ophiobolin G (3) from a culture of marine-derived fungus of Emericella variecolor. Ophiobolins 1–3 inhibited biofilm formation of Mycobacterium smegmatis with MICs of 4.1–65 μM, whereas these compounds did not show… CONTINUE READING
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