Marine bacterial inhibitors from the sponge-derived fungus Aspergillus sp.

  title={Marine bacterial inhibitors from the sponge-derived fungus Aspergillus sp.},
  author={Ya-ming Zhou and A. Debbab and V. Wray and Wenhan Lin and B. Schulz and R. Tr{\'e}pos and C. Pile and C. Hellio and P. Proksch and A. Aly},
  journal={Tetrahedron Letters},
Abstract Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated from the Mediterranean sponge Tethya aurantium , yielded a new tryptophan derived alkaloid, 3-((1-hydroxy-3-(2-methylbut-3-en-2-yl)-2-oxoindolin-3-yl)methyl)-1-methyl-3,4-dihydrobenzo[ e ][1,4]diazepine-2,5-dione ( 1 ), and a new meroterpenoid, austalide R ( 2 ), together with three known compounds ( 3 – 5 ). The structures of the new compounds were unambiguously elucidated on the basis of… Expand

Figures and Tables from this paper

New secondary metabolites from the mangrove-derived fungus Aspergillus sp. AV-2
Abstract Chemical investigation of the mangrove-derived fungus Aspergillus sp. AV-2 following fermentation on solid rice medium led to the isolation of a new phenyl pyridazine derivative (1) and aExpand
Phenolic bisabolanes from the sponge-derived fungus Aspergillus sp.
Two new phenolic bisabolane sesquiterpenes, asperchondols A and B, together with seven known analogues and four known diphenyl ethers were obtained from Aspergillus sp. Expand
A New Cyclic Hexapeptide and a New Isocoumarin Derivative from the Marine Sponge-Associated Fungus Aspergillus similanensis KUFA 0013
Only compound 2 exhibited weak activity against the three cancer cell lines, and neither of them showed antibacterial activity. Expand
Lophiostomin A–D: new 3,4-dihydroisocoumarin derivatives from the endophytic fungus Lophiostoma sp. Sigrf10
Four new 3,4-dihydroisocoumarin congeners, named lophiostomin A–D (1–4), together with two known α-pyridones (5 and 6) were isolated from cultures of the endophytic fungus Lophiostoma sp. Sigrf10Expand
Terpenoids from the Deep-Sea-Derived Fungus Penicillium thomii YPGA3 and Their Bioactivities
A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicillium thomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analoguesExpand
New Indole Diketopiperazine Alkaloids from Soft Coral‐Associated Epiphytic Fungus Aspergillus sp. EGF 15‐0‐3
Three new indole diketopiperazine alkaloids, 11‐methylneoechinulin E and variecolorin M, and (+)‐variecolorin G, along with 12 known analogs, were isolated from a soft coral‐associated epiphyticExpand
α‐Glucosidase Inhibitors from the Fungus Aspergillus terreus 3.05358
Amauromine B and austalide N exhibited more potent α‐glucosidase inhibitory activities than the positive control acarbose, and the absolute configuration of 1 was unambiguously established by single crystal X‐ray diffraction analysis. Expand
Study literature showed that many fungal genera isolated from the marine sponge dominated the genus Acremonium, Aspergillus, Penicillium, Phoma, and Fusarium, indicating the important role of marine-derived fungi in the discovery of drug compounds. Expand
The Sponge-Associated Fungus Eurotium chevalieri MUT 2316 and its Bioactive Molecules: Potential Applications in the Field of Antifouling
The objective of this work was to evaluate the antifouling potency of 7 compounds isolated from the sponge derived fungus Eurotium chevalieri MUT 2316, with promising results for echinulin, neoechinulin A, dihydroauroglaucin and flavoglaucin, respectively. Expand
Bioactive Alkaloids from Genus Aspergillus: Mechanistic Interpretation of Their Antimicrobial and Potential SARS-CoV-2 Inhibitory Activity Using Molecular Modelling
This review aimed to comprehensively explore the diverse alkaloids isolated and identified from different species of genus Aspergillus that were found to be associated with different marine organisms regarding their chemistry and biology and showed anti-infective potential. Expand


New Austalides from the Sponge-Associated Fungus Aspergillus sp.†
Chromatographic separation of a crude extract obtained from the fungus Aspergillus sp., isolated from the Mediterranean sponge Tethya aurantium, yielded five new meroterpenoid metabolites, austalidesExpand
Alkaloids from the sponge-associated fungus aspergillus sp.
Seven new alkaloids including tryptoquivaline K (1) and fumiquinazolines K–P (2–7), bearing a rare 1-aminocyclopropane-1-carboxylic acid residue, together with six known compounds (8–13), wereExpand
(+)‐Flavipucine, the Missing Member of the Pyridione Epoxide Family of Fungal Antibiotics
From the culture extracts of the endophytic fungus, Phoma sp., isolated from the plant Salsola oppositifolia, five secondary metabolites were isolated and characterized. On biomalt agar medium, theExpand
Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants.
In a study to discover potential anticancer agents from rhizosphere fungi of Sonoran desert plants cytotoxic EtOAc extracts of four Aspergillus strains have been investigated. Two new metabolites,Expand
Cyclic tripeptides from the halotolerant fungus Aspergillus sclerotiorum PT06-1.
Chemical transformations of 12 and 13 proved that sclerotiotides D-K (4-11) were artifacts probably formed during the fermentation or subsequent isolation steps, and all 13 cyclic tripeptides have been evaluated for their antimicrobial and cytotoxic effects. Expand
Ardeemins and cytochalasins from Aspergillus terreus residing in Artemisia annua.
Three new alkaloids, 15b-dehydro-5- N-acetylardeemin ( 3), 10-phenyl-[12]-cytochalasins Z16 ( 6) and Z17 ( 7), were characterized from the liquid culture of the endophytic fungus ASPERGILLUS TERREUSExpand
Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044.
Two new oxepin-containing (1 and 2) and two diketopiperazine-type alkaloids (3 and 4) have been isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5044. The structures ofExpand
Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula.
Seven new drimane sesquiterpenoids were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula, by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Expand
Cytotoxic polyketides from a marine-derived fungus Aspergillus glaucus.
Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structuresExpand
Ophiobolin sesterterpenoids and pyrrolidine alkaloids from the sponge-derived fungus aspergillus ustus
Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidineExpand