Marine Viruses Exploit Their Host's Two-Component Regulatory System in Response to Resource Limitation

@article{Zeng2012MarineVE,
  title={Marine Viruses Exploit Their Host's Two-Component Regulatory System in Response to Resource Limitation},
  author={Qinglu Zeng and Sallie W. Chisholm},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={124-128}
}
Phosphorus (P) availability, which often limits productivity in marine ecosystems, shapes the P-acquisition gene content of the marine cyanobacteria Prochlorococcus [1-4] and its viruses (cyanophages). As in other bacteria, in Prochlorococcus these genes are regulated by the PhoR/PhoB two-component regulatory system that is used to sense and respond to P availability and is typical of signal transduction systems found in diverse organisms. Replication of cyanophage genomes requires a… 
Transcriptomic response during phage infection of a marine cyanobacterium under phosphorus-limited conditions.
TLDR
It is found that the host pstS transcript number per cell decreased after infection, however, it was still much higher in the P-limited infected cells than that in the nutrient-replete cells, which may help maintain the host phosphate uptake rate during infection.
Viral infection of marine picoplankton under nutrient depletion conditions : pseudolysogeny and magic spot nucleotides
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This thesis shows that the Synechococcus host mazG is dispensable for growth under normal laboratory conditions, and suggests that cyanophage and host MazG may have additional functions in phosphate metabolism and controlling DNA integrity, a hypothesis strengthened by experimental evidence.
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TLDR
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Integration of the cyanophage-encoded phosphate binding protein into the cyanobacterial phosphate uptake system
  • Fangxin Zhao, Xingqin Lin, +7 authors Qinglu Zeng
  • Biology
  • 2021
TLDR
It is shown that the cyanophage P-SSM2 PstS protein was abundant in the infected Prochlorococcus NATL2A cells and the host phosphate uptake rate was enhanced after infection, consistent with biochemical and structural analyses showing that the phage Pst S protein is indeed a high-affinity phosphate-binding protein.
Phage puppet masters of the marine microbial realm
TLDR
The ‘royal family model’ is proposed as a hypothesis to describe successional patterns of bacteria and phages over time in marine systems, where despite high richness and significant seasonal differences, only a small number of phages appear to continually dominate a given marine ecosystem.
Transcriptome Analysis of a Bloom-Forming Cyanobacterium Microcystis aeruginosa during Ma-LMM01 Phage Infection
TLDR
It is suggested that unlike other known T4-like phages, Ma-LMM01 achieves three sequential gene expression patterns with no change in host promoter activity, and this type of infection that does not cause significant changes in host transcriptional levels may be advantageous in allowing Ma- lMM01 to escape host defense systems while maintaining host photosynthesis.
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