Marine Microorganisms as Source of Stereoselective Esterases and Ketoreductases: Kinetic Resolution of a Prostaglandin Intermediate

@article{Vitis2014MarineMA,
  title={Marine Microorganisms as Source of Stereoselective Esterases and Ketoreductases: Kinetic Resolution of a Prostaglandin Intermediate},
  author={V. D. Vitis and B. Guidi and Martina L. Contente and T. Granato and P. Conti and F. Molinari and E. Crotti and F. Mapelli and S. Borin and D. Daffonchio and D. Romano},
  journal={Marine Biotechnology},
  year={2014},
  volume={17},
  pages={144-152}
}
A screening among bacterial strains isolated from water-brine interface of the deep hypersaline anoxic basins (DHABs) of the Eastern Mediterranean was carried out for the biocatalytical resolution of racemic propyl ester of anti-2-oxotricyclo[2.2.1.0]heptan-7-carboxylic acid (R,S)-1, a key intermediate for the synthesis of d-cloprostenol. Bacillus horneckiae 15A gave highly stereoselective reduction of (R,S)-1, whereas Halomonas aquamarina 9B enantioselectively hydrolysed (R,S)-1; in both cases… Expand
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