Marine Cyclic Guanidine Alkaloids Monanchomycalin B and Urupocidin A Act as Inhibitors of TRPV1, TRPV2 and TRPV3, but not TRPA1 Receptors

@article{Korolkova2017MarineCG,
  title={Marine Cyclic Guanidine Alkaloids Monanchomycalin B and Urupocidin A Act as Inhibitors of TRPV1, TRPV2 and TRPV3, but not TRPA1 Receptors},
  author={Yuliya V. Korolkova and T. Makarieva and K. Tabakmakher and L. Shubina and Ekaterina K. Kudryashova and Y. Andreev and I. Mosharova and Hyi-Seung Lee and Y. Lee and S. Kozlov},
  journal={Marine Drugs},
  year={2017},
  volume={15}
}
Marine sponges contain a variety of low-molecular-weight compounds including guanidine alkaloids possessing different biological activities. Monanchomycalin B and urupocidin A were isolated from the marine sponge Monanchora pulchra. We found that they act as inhibitors of the TRPV1, TRPV2, and TRPV3 channels, but are inactive against the TRPA1 receptor. Monanchomycalin B is the most active among all published marine alkaloids (EC50 6.02, 2.84, and 3.25 μM for TRPV1, TRPV2, and TRPV3… Expand
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