Marijuana smoking: factors that influence the bioavailability of tetrahydrocannabinol.

@article{PrezReyes1990MarijuanaSF,
  title={Marijuana smoking: factors that influence the bioavailability of tetrahydrocannabinol.},
  author={Mario P{\'e}rez-Reyes},
  journal={NIDA research monograph},
  year={1990},
  volume={99},
  pages={
          42-62
        }
}
Marijuana smoking is the most commonly used method for the selfadministration of delta-9-tetrahydrocannabinol (THC) the active principle of marijuana. The inhalation of marijuana smoke induces subjective effects (“high”) that are rapidly perceived by the smokers. The perception of these effects allows smokers the capacity to achieve, within certain limits, their desired level of high by changing the puff volume, the interval between puffs, and the number of puffs taken. Therefore, the manner in… 
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References

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TLDR
The results indicate that, irrespective of the potency of the marihuana, the pattern of smoking was much the same and the magnitude of the subjective high, heart rate acceleration, THC, and 9‐carboxy THC plasma concentrations were proportional to potency.
The Clinical Pharmacology and Dynamics of Marihuana Cigarette Smoking
TLDR
The results indicate that each subject smoked his or her two cigarettes at a similar rate and the plasma concentrations of THC, the self‐reported psychologic effects, and the heart rate acceleration produced by the smoking of the two cigarettes were identical between the sexes.
Pharmacology of orally administered Δ9‐tetrahydrocannabinol
A systematic study of the oral administration of 35 mg. of Δ9‐tetrahydrocannabinol (Δ9‐THC) in 5 different vehicles indicates that the speed and degree of absorption are greatly influenced by the
Detection of Recent Cannabis Use by Saliva Δ9-THC Radioimmunoassay
TLDR
A reliable saliva assay for cannabinoids is described which provides positive results for 3-5 hrs after smoking and thus detects recent exposure to marijuana, and offers the advantages of both convenience and reliability.
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TLDR
This work has been directed towards the use of the amyl side chain for linking cannabinoid compounds to proteins to form immunogens, which has the potential to develop a highly specific assay for 11-nor-9-carboxy-delta- 9-THC in plasma.
Intravenous Injection in Man of Δ9-Tetrahydrocannabinol and 11-OH-Δ9-Tetrahydrocannabinol
TLDR
Intravenous infusion of this preparation to humans indicates that both tetrahydrocannabinols are equally potent in producing the typical marihuana-like pschological and physiological effects.
Determination of delta 9-tetrahydrocannabinol in human blood and saliva by high-performance liquid chromatography with amperometric detection.
A rapid, sensitive and selective determination of delta 9-tetrahydrocannabinol (THC) in human plasma, serum and saliva was developed with high-performance liquid chromatography with electrochemical
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TLDR
In this sensitive and specific radioimmunoassay for delta-9-tetrahydrocannabinol, an iodinated tracer with high specific activity and a solid-phase separation are used and results by the two methods of analysis correlate well.
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