Corpus ID: 17344361

Marijuana smoking: effects of varying puff volume and breathhold duration.

@article{Azorlosa1995MarijuanaSE,
  title={Marijuana smoking: effects of varying puff volume and breathhold duration.},
  author={Julian. Azorlosa and Mark K. Greenwald and Maxine L. Stitzer},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={272 2},
  pages={
          560-9
        }
}
Two studies were conducted to quantify biological and behavioral effects resulting from exposure to controlled doses of marijuana smoke. In one study, puff volume (30, 60 and 90 ml) and in a second study, breathhold duration (0, 10 and 20 sec) were systematically varied while holding constant other smoking topography parameters (number of puffs = 10, interpuff interval = 60 sec and inhalation volume = 25% of vital capacity). Each study also varied levels of delta 9-tetrahydro-cannabinol… Expand
Marijuana's dose-dependent effects in daily marijuana smokers.
TLDR
Although changes in inhalation patterns as a function of marijuana strength likely minimized the difference between dose conditions, dose-dependent differences in marijuana's cardiovascular effects and ratings of craving were observed, whereas subjective ratings of marijuana effects did not significantly vary as afunction of dose. Expand
Antinociceptive, subjective and behavioral effects of smoked marijuana in humans.
TLDR
Marijuana produced significant dose-dependent antinociception (increased finger withdrawal latency) and biobehavioral effects, and Naltrexone did not significantly influence marijuana dose-effect curves, suggesting no role of endogenous opiates in marijuana-induced antinOCiception under these conditions. Expand
Comparative Effects of Alcohol and Marijuana on Mood, Memory, and Performance
TLDR
Alcohol, but not marijuana, slightly impaired performance in a number recognition test, and both drugs produced comparable impairment in digit-symbol substitution and word recall tests, but had no effect in time perception and reaction time tests. Expand
Acute and Residual Effects of Marijuana in Humans
TLDR
Although robust acute effects of marijuana were found on subjective and physiological measures, and on smooth pursuit eye tracking performance, no effects were evident the day following administration, indicating that the residual effects of smoking a single marijuana cigarette are minimal. Expand
Sedative, Stimulant, and Other Subjective Effects of Marijuana: Relationships to Smoking Techniques
TLDR
The major finding of the study was that the long, relative to the short, breath-holding duration increased "high" ratings after smoking marijuana, but not placebo, which occurred equally after smoking of marijuana and placebo. Expand
Acute effects of cannabis on breath-holding duration.
TLDR
Findings indicate that cannabis may exacerbate distress intolerance (via shorter breath-holding durations) as compared to less frequent cannabis users, frequent users display tolerance to cannabis' acute effects including increased ability to tolerate respiratory distress when holding breath. Expand
Acute effects of THC on time perception in frequent and infrequent cannabis users
TLDR
A psychoactive dose of THC increases internal clock speed as indicated by time overestimation and underproduction as well as blunted in chronic cannabis smokers who did not otherwise have altered baseline time perception. Expand
Acute Marijuana Effects on Human Risk Taking
TLDR
Shifts in trial-by-trial response probabilities at the highest dose suggested a change in sensitivity to both reinforced and losing risky outcomes, suggesting altered sensitivity to consequences may be a mechanism in drug-induced changes in risk taking. Expand
Oral fluid cannabinoid concentrations following controlled smoked cannabis in chronic frequent and occasional smokers
TLDR
As THCCOOH is not present in cannabis smoke, its presence in OF minimizes the potential for false positive results from passive environmental smoke exposure, and can identify oral THC ingestion, while OF THC cannot. Expand
Marijuana Effects on Sensitivity to Reinforcement in Humans
TLDR
Quantitative and graphical analyses revealed that the higher doses produced considerable periods of time spent on the decreasing option despite earning few reinforcers, which could not be accounted for by a change in response rates. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
Breathhold duration and response to marijuana smoke
TLDR
Typical marijuana effects were observed under each of the breathhold conditions, but there was little evidence that response to marijuana was a function of breathhold duration. Expand
Human cigarette smoking: effects of puff and inhalation parameters on smoke exposure.
TLDR
It is shown that puff volume is an important determinant of tobacco smoke exposure, but that inhalation components of smoking behavior, at least within the range of parameters tested, have no effect on nicotine exposure levels. Expand
Effects of tetrahydrocannabinol content on marijuana smoking behavior, subjective reports, and performance
TLDR
Although subjects adjusted their smoking of cigarettes varying in THC content, dose-related effects of marijuana were obtained on several measures and suggest that precise control of smoking behavior would improve the accuracy of marijuana dose delivery. Expand
Comparison of effects of marihuana cigarettes of three different potencies
TLDR
The results indicate that, irrespective of the potency of the marihuana, the pattern of smoking was much the same and the magnitude of the subjective high, heart rate acceleration, THC, and 9‐carboxy THC plasma concentrations were proportional to potency. Expand
Effects of varying marijuana smoking profile on deposition of tar and absorption of CO and delta-9-THC
TLDR
The longer BHT significantly increased both percent retention of tar in the lung and the pre- to postsmoking rise in blood COHb, serum THC and heart rate, independent of puff volume and number. Expand
Tar, CO and Δ 9-THC delivery from the 1st and 2nd halves of a marijuana cigarette
TLDR
Compared to the distal half, smoking the proximal half of a marijuana cigarette delivered more tar, carbon monoxide and THC to the smoker's lungs, as indicated by a greater amount of inhaled tar and a larger boost in both blood carboxyhemoglobin and serum THC. Expand
Pulmonary hazards of smoking marijuana as compared with tobacco.
TLDR
It is concluded that smoking marijuana, regardless of tetrahydrocannabinol content, results in a substantially greater respiratory burden of carbon monoxide and tar than smoking a similar quantity of tobacco. Expand
Time course of end-expired carbon monoxide concentration is important in studies of cigarette smoking.
TLDR
End-expired carbon monoxide concentration (EECO) was measured with an Ecolyzer 2000 series analyser before smoking, 1 min after finishing smoking, and then at intervals up to 1 h after smoking to study the relationship between smoking and EECO levels. Expand
Is alveolar carbon monoxide an unreliable index of carboxyhaemoglobin changes during smoking in man?
TLDR
Alveolar CO measurements give a useful estimate of carboxyhaemoglobin level if the subject has not smoked for at least half an hour but that measurements of alveolars CO boost are useless since the act of smoking interferes with alveolar sampling. Expand
Psychopharmacology: The Third Generation of Progress
  • J. Krystal
  • The Yale Journal of Biology and Medicine
  • 1989
Although the discussions are comprehensive, this book is not an exhaustive reference work. The result of this organization is an extremely usable text for the clinician. The organization and style ofExpand
...
1
2
3
...