Marijuana is both antiemetic and proemetic

@article{Lu2015MarijuanaIB,
  title={Marijuana is both antiemetic and proemetic},
  author={Marvin Louis Roy Lu and Markus D. Agito},
  journal={Cleveland Clinic Journal of Medicine},
  year={2015},
  volume={82},
  pages={429 - 434}
}
Although marijuana is sometimes used to treat chemotherapy-induced nausea and vomiting, when used long-term it can have a paradoxical hyperemetic effect known as cannabinoid hyperemesis syndrome. Knowledge of this phenomenon may reduce the ordering of unnecessary and expensive investigations, as well as inappropriate medical and surgical treatment in patients presenting with recurrent vomiting of unknown cause. This article reviews the pathophysiology, clinical presentation, diagnosis, and… 
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Cannabinoid hyperemesis syndrome
TLDR
Understanding the diagnostic criteria and risk factors associated with CHS may reduce the ordering of unnecessary and expensive investigations, and pursuing inappropriate medical and surgical treatments.
Is haloperidol the wonder drug for cannabinoid hyperemesis syndrome?
TLDR
The present report highlights the use of haloperidol as an agent that successfully and safely treats the unrelenting symptoms of CHS.
Cannabinoid Hyperemesis: An Erratic Syndrome Linked with Cannabis Abuse
TLDR
This study confirmed the previously stated outcomes of cannabinoid hyperemesis syndrome and suggested that CHS should be measured in younger patients with chronic cannabis use and repeated nausea, vomiting, as well as pain in the abdominal.
Capsaicin Cream for Treatment of Cannabinoid Hyperemesis Syndrome in Adolescents: A Case Series
TLDR
2 adolescent patients with nausea, vomiting, and abdominal pain in the setting of chronic cannabis use whose symptoms were not relieved by standard antiemetic therapies, but who responded well to topical capsaicin administration in the pediatric emergency department are described.
Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms.
TLDR
Extended high doses of the main psychotropic compound in cannabis result in changes to the endocannabinoid system by acting on the cannabinoid 1 (CB1) receptor, which may cause Cannabinoid hyperemesis syndrome.
Pharmacological management of cannabinoid hyperemesis syndrome: an update of the clinical literature
TLDR
Antipsychotics (such as haloperidol, benzodiazepines, and/or capsaicin cream appear to be the most efficacious in the treatment of this unique disorder.
Cannabinoid Hyperemesis Syndrome
TLDR
The clinical presentation and treatment for cannabinoid hyperemesis syndrome is described and theories proposed to explain CHS including chronic stimulation of the CB1 receptor, binding of theCB1 receptor causing decreased gut motility, desensitization of CB1 receptors, or interaction of the TRVP-1 receptor with the ennocannabinoid system are proposed.
[Cannabinoid hyperemesis syndrome: A review of the literature].
Cannabinoid hyperemesis syndrome A paradoxical reaction to marijuana
TLDR
A 32-year-old man presents to the ED with 7 out of 10 epigastric pain and 15 episodes of vomiting during the past 10 hours, and you suspect cannabinoid hyperemesis syndrome (CHS)—a relatively newly described disease.
Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment—a Systematic Review
TLDR
Cannabinoid hyperemesis syndrome is a cyclic vomiting syndrome, preceded by daily to weekly cannabis use, usually accompanied by symptom improvement with hot bathing, and resolution with cessation of cannabis, which appears to be the best treatment.
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TLDR
This work describes the syndrome in 4 adult patients for whom extensive gastrointestinal evaluations failed to identify another clear cause of cannabinoid hyperemesis, and concludes that cessation of marijuana use resulted in the alleviation of their symptoms.
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TLDR
Cannabinoid hyperemesis is a cluster of symptoms characterized by chronic cannabis abuse, cyclical vomiting and compulsive bathing behaviours that can be missed unless an adequate history is taken of illicit drug ingestion.
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TLDR
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TLDR
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TLDR
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