Marijuana is both antiemetic and proemetic

@article{Lu2015MarijuanaIB,
  title={Marijuana is both antiemetic and proemetic},
  author={Marvin Louis Roy Lu and Markus D. Agito},
  journal={Cleveland Clinic Journal of Medicine},
  year={2015},
  volume={82},
  pages={429 - 434}
}
Although marijuana is sometimes used to treat chemotherapy-induced nausea and vomiting, when used long-term it can have a paradoxical hyperemetic effect known as cannabinoid hyperemesis syndrome. Knowledge of this phenomenon may reduce the ordering of unnecessary and expensive investigations, as well as inappropriate medical and surgical treatment in patients presenting with recurrent vomiting of unknown cause. This article reviews the pathophysiology, clinical presentation, diagnosis, and… 

Figures and Tables from this paper

Cannabinoid hyperemesis syndrome
TLDR
Understanding the diagnostic criteria and risk factors associated with CHS may reduce the ordering of unnecessary and expensive investigations, and pursuing inappropriate medical and surgical treatments.
Is haloperidol the wonder drug for cannabinoid hyperemesis syndrome?
TLDR
The present report highlights the use of haloperidol as an agent that successfully and safely treats the unrelenting symptoms of CHS.
Cannabinoid Hyperemesis: An Erratic Syndrome Linked with Cannabis Abuse
TLDR
This study confirmed the previously stated outcomes of cannabinoid hyperemesis syndrome and suggested that CHS should be measured in younger patients with chronic cannabis use and repeated nausea, vomiting, as well as pain in the abdominal.
Capsaicin Cream for Treatment of Cannabinoid Hyperemesis Syndrome in Adolescents: A Case Series
TLDR
2 adolescent patients with nausea, vomiting, and abdominal pain in the setting of chronic cannabis use whose symptoms were not relieved by standard antiemetic therapies, but who responded well to topical capsaicin administration in the pediatric emergency department are described.
Cannabinoid Hyperemesis Syndrome: A Review of Potential Mechanisms.
TLDR
Extended high doses of the main psychotropic compound in cannabis result in changes to the endocannabinoid system by acting on the cannabinoid 1 (CB1) receptor, which may cause Cannabinoid hyperemesis syndrome.
Pharmacological management of cannabinoid hyperemesis syndrome: an update of the clinical literature
TLDR
Antipsychotics (such as haloperidol, benzodiazepines, and/or capsaicin cream appear to be the most efficacious in the treatment of this unique disorder.
Cannabinoid Hyperemesis Syndrome
TLDR
The clinical presentation and treatment for cannabinoid hyperemesis syndrome is described and theories proposed to explain CHS including chronic stimulation of the CB1 receptor, binding of theCB1 receptor causing decreased gut motility, desensitization of CB1 receptors, or interaction of the TRVP-1 receptor with the ennocannabinoid system are proposed.
[Cannabinoid hyperemesis syndrome: A review of the literature].
Cannabinoid hyperemesis syndrome A paradoxical reaction to marijuana
TLDR
A 32-year-old man presents to the ED with 7 out of 10 epigastric pain and 15 episodes of vomiting during the past 10 hours, and you suspect cannabinoid hyperemesis syndrome (CHS)—a relatively newly described disease.
Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment—a Systematic Review
TLDR
Cannabinoid hyperemesis syndrome is a cyclic vomiting syndrome, preceded by daily to weekly cannabis use, usually accompanied by symptom improvement with hot bathing, and resolution with cessation of cannabis, which appears to be the best treatment.
...
1
2
3
...

References

SHOWING 1-10 OF 35 REFERENCES
Cannabinoid Hyperemesis and Compulsive Bathing: A Case Series and Paradoxical Pathophysiological Explanation
TLDR
This work describes the syndrome in 4 adult patients for whom extensive gastrointestinal evaluations failed to identify another clear cause of cannabinoid hyperemesis, and concludes that cessation of marijuana use resulted in the alleviation of their symptoms.
Cannabinoid Hyperemesis: Marijuana Puts Patients in Hot Water
TLDR
Cannabinoid hyperemesis is a cluster of symptoms characterized by chronic cannabis abuse, cyclical vomiting and compulsive bathing behaviours that can be missed unless an adequate history is taken of illicit drug ingestion.
Pediatric Cannabinoid Hyperemesis: Two Cases
TLDR
The cannabinoidoid hyperemesis syndrome is described in 2 pediatric patients, for whom extensive gastrointestinal workups failed to identify a clear cause and cessation of marijuana use resulted in the alleviation of their symptoms.
Cannabinoid Hyperemesis Relieved by Compulsive Bathing
TLDR
2 cases of cannabinoid hyperemesis are reported that demonstrate this unusual adverse effect of marijuana use and the thermoregulatory role of endocannabinoids may be responsible for the patient's need for hot showers.
Cannabinoid Hyperemesis Syndrome: Case Report of a Paradoxical Reaction with Heavy Marijuana Use
TLDR
The use of lorazepam is presented as an agent that successfully and safely treats the tenacious symptoms of CHS and is built upon existing hypotheses to try to explain why a substance that has been used for thousands of years is only now beginning to cause this paradoxical hyperemesis syndrome.
Cannabinoid hyperemesis syndrome: literature review and proposed diagnosis and treatment algorithm.
TLDR
Increased healthcare provider awareness of CHS as a cause of nausea, vomiting, and abdominal pain coupled with an attentiveness to focused history taking can lead to effective treatment through cannabis cessation.
The emerging role of cannabinoid neuromodulators in symptom management
TLDR
The benefits of this novel class of medications in cancer may extend beyond CINV, as indicated by data from preclinical studies and animal models.
Cannabinoid hyperemesis: a case series.
Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males
TLDR
Whether clinical or gastric emptying data discriminate patients labeled as having CVS from functional vomiting (FV) or irritable bowel syndrome (IBS) is evaluated.
...
1
2
3
4
...