Marijuana in the management of amyotrophic lateral sclerosis

@article{Carter2001MarijuanaIT,
  title={Marijuana in the management of amyotrophic lateral sclerosis},
  author={Gregory T Carter and B S Rosen},
  journal={American Journal of Hospice and Palliative Medicine},
  year={2001},
  volume={18},
  pages={264 - 270}
}
  • G. Carter, B. S. Rosen
  • Published 1 July 2001
  • Psychology
  • American Journal of Hospice and Palliative Medicine
Marijuana has been proposed as treatment for a widening spectrum of medical conditions. Marijuana is a substance with many properties that may be applicable to the management of amyotrophic lateral sclerosis (ALS). These include analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. In addition, marijuana has now been shown to have strong antioxidative and neuroprotective effects, which may prolong neuronal cell survival. In areas where it is… 
View on SAGE
files.iowamedicalmarijuana.org
52 Citations
Highly Influential Citations
2
Background Citations
22

Tables from this paper

52 Citations

Medical marijuana: emerging applications for the management of neurologic disorders.
  • G. Carter, V. Ugalde
  • Medicine
    Physical medicine and rehabilitation clinics of North America
  • 2004
Can cannabinoids be a potential therapeutic tool in amyotrophic lateral sclerosis?
TLDR
A short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids are provided.
Cannabis and Amyotrophic Lateral Sclerosis: Hypothetical and Practical Applications, and a Call for Clinical Trials
TLDR
Based on the currently available scientific data, it is reasonable to think that cannabis might significantly slow the progression of ALS, potentially extending life expectancy and substantially reducing the overall burden of the disease.
Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis.
Current pharmacological management of amyotropic lateral sclerosis and a role for rational polypharmacy
TLDR
Based on the available data, it is the opinion that combination drug therapies should be considered for future clinical trials.
Pharmacologic Approaches to the Treatment of Amyotrophic Lateral Sclerosis
TLDR
Gene transfer of VEGF or glial cell-line derived neurotrophic factor, anti-inflammatory COX-2 inhibitors, and minocycline have had particularly promising results in mice.
Cannabis therapy in neurological disorders: Recent advances and perspectives
TLDR
Although there are clinical studies supporting the use of cannabis preparations as adjuvant therapy in neurological disorders, more investigations are needed to assess their safety and efficacy.
Narrative review of the safety and efficacy of marijuana for the treatment of commonly state-approved medical and psychiatric disorders
TLDR
There is insufficient evidence to support the recommendation of medical marijuana for the treatment of the most common medical and psychological conditions for which it has been allowed at the state level.
PHARMACOTHERAPY OF AMYOTROPHIC LATERAL SCLEROSIS: AN INSIGHT
TLDR
Current therapeutic approaches including recent advances in pharmacological treatment strategies along with nutrition and dietary supplements based on the potential to delay onset of disease, retard the progression of Disease, extend the lifespan and improve the quality of life of patients are reviewed.
Mechanism and implications of traditional Chinese medicine in amyotrophic lateral sclerosis therapy
TLDR
Chinese herbal medicines have been explored as a therapeutic option to manage clinical manifestations of ALS and other neurological diseases and the therapeutic benefits of CHMs on various neurodegenerative disorders, particularly ALS are summarized.
...
...

References

SHOWING 1-10 OF 76 REFERENCES
Marijuana: medical implications.
TLDR
Adverse effects from marijuana use include decreased coordination, epithelial damage to the lungs, increased risk of infection, cardiovascular effects and cognitive deficits.
Medicinal marijuana: a comprehensive review.
TLDR
A comprehensive literature review of the topic found that patients who are best suited to medicinal marijuana will be those who will gain substantial benefit to offset these risks, and who have failed a well-documented, compliant and comprehensive approach to standard therapies.
Comprehensive management of amyotrophic lateral sclerosis.
  • G. Carter, R. Miller
  • Medicine, Psychology
    Physical medicine and rehabilitation clinics of North America
  • 1998
Expanding the role of hospice care in amyotrophic lateral sclerosis
TLDR
There is a great need to increase awareness of both patients and clinicians regarding the effectiveness of hospice in the care of advanced ALS patients, because hospice services are far underutilized in this setting.
Health aspects of cannabis.
Marijuana, receptors and immunomodulation.
TLDR
It has recently been shown that THC can enhance production or release of pro-inflammatory cytokines, including augmented release of IL1, TNF alpha, and IL6 activity.
Endocannabinoids and vascular function.
  • C. Hillard
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 2000
TLDR
Two arachidonic acid analogs, N-arachidonylethanolamine and 2-arACHidonylglycerol are hypothesized to function as endogenous ligands of the CB(1) receptor, and they are the subjects of this review.
Recent clinical experience with dronabinol
Suppression of neuropathic pain behavior in rats by a non-psychotropic synthetic cannabinoid with NMDA receptor-blocking properties
Medical marijuana: a trial of science and politics.
TLDR
Donald Abrams, MD, the consortium's chairman, has been trying to devise a trial to compare the efficacy of inhaled marijuana with dronabinol as an appetite stimulant for patients with HIV wasting syndrome, and says there are a lot of politics around this field.
...
...