Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?

  title={Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?},
  author={Kathryn A. Seely and Paul L. Prather and Laura P. James and Jeffery H. Moran},
  journal={Molecular interventions},
  volume={11 1},
The principal psychoactive component of marijuana, Δ(9)-tetrahydrocannabinol (THC), activates CB1 cannabinoid receptors (CB1Rs). Unfortunately, pharmacological research into the design of effective THC analogs has been hampered by psychiatric side effects. THC-based drug design of a less academic nature, however, has led to the marketing of "synthetic marijuana," labeled as K2 or "Spice," among other terms, which elicits psychotropic actions via CB1R activation. Because of structural… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 43 extracted citations


Publications referenced by this paper.
Showing 1-10 of 124 references

The Science of Marijuana, 2nd ed

  • LL Iversen
  • 2008
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…