Marijuana, absinthe and the central nervous system

@article{Castillo1975MarijuanaAA,
  title={Marijuana, absinthe and the central nervous system},
  author={Jorge del Castillo and M W Anderson and George M. Rubottom},
  journal={Nature},
  year={1975},
  volume={253},
  pages={365-366}
}
THERE are striking similarities between the psychological actions of the liqueur absinthe1 and the experiences frequently reported by users of marijuana2. We have therefore compared the properties of thujone and tetrahydrocannabinol (THC), which are believed to be the active principles of Artemisia absinthium and Cannabis sativa, respectively. Both substances are terpenoid, derived from the essential oils absinthol and cannabinol, and are formed by similar biosynthetic mechanisms3,4. 
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Absinthe, epileptic seizures and Valentin Magnan.
  • M. Eadie
  • Medicine
  • The journal of the Royal College of Physicians of Edinburgh
  • 2009
TLDR
An examination of Valentin Magnan's published investigations suggests that his science was very adequate by the standards of his time, and that he had shown that an alcohol-soluble component of wormwood did produce lapses of consciousness, myoclonic jerks and tonic-clonic convulsions in animals. Expand
Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification.
TLDR
Alpha-thujone in absinthe and herbal medicines is a rapid-acting and readily detoxified modulator of the GABA-gated chloride channel. Expand
Absinthe , epileptic seizures and
Absinthe is an alcoholic liquor containing extracts from the wormwood plant. It was widely consumed in France in the late nineteenth century. Its production was banned in 1915, partly because it was… Expand
Pharmacology and toxicology of absinthe
TLDR
Absinthe is a flavoured distilled liquor, emerald green in colour, turning to cloudy, opalescent white when mixed with water, which is responsible for the pharmacological and toxicological properties of absinthe. Expand
Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone.
TLDR
Analysis of current responses to exogenous GABA revealed that 1a reduced their amplitude, affecting their onset, desensitization, and deactivation, suggesting an effect on receptor gating, supporting the effects of 1a on GABAergic inhibition as being due to specific interactions with GABA(A)Rs. Expand
Thujone--cause of absinthism?
TLDR
Thujone plays none, or only a minor role in the clinical picture of absinthism, and the hallucinogenic potential of vintage absinthes can be assessed being rather low because the historic products also comply with today's maximum limits derived to exclude such effects. Expand
Thujone Exhibits Low Affinity for Cannabinoid Receptors But Fails to Evoke Cannabimimetic Responses
TLDR
The hypothesis that activation of cannabinoid receptors is responsible for the intoxicating effects of thujone is not supported by the present data. Expand
Cannabinoids and membrane-bound enzymes.
  • A. Mellors
  • Chemistry, Medicine
  • Advances in the biosciences
  • 1978
TLDR
Molar volume correlations indicate that the specificity of the inhibition is not determined by the partition coefficient or the ability of the cannabinoid to protect erythrocytes against hypotonic hemolysis. Expand
Absinthe: return of the Green Fairy.
TLDR
This paper reviews some of the historical aspects of absinthe and aims to shed light on the mechanism of action and neurotoxicology of this the Green Fairy. Expand
Toxic essential oils. Part V: Behaviour modulating and toxic properties of thujones and thujone-containing essential oils of Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.
TLDR
The results strongly imply that the toxic and behaviour-modulating activity of the oils (hundreds of constituents) should not be associated exclusively with thujones, and the amount and toxicity of other constituents should be taken into consideration when making risk assessment and determining the regulatory status of plants in food and medicines. Expand
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