Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man.

@article{Lemberger1970MarihuanaSO,
  title={Marihuana: studies on the disposition and metabolism of delta-9-tetrahydrocannabinol in man.},
  author={Louis Lemberger and Stephen David Silberstein and Julius See Axelrod and IrwinJ. Kopin},
  journal={Science},
  year={1970},
  volume={170 3964},
  pages={
          1320-2
        }
}
Delta(9)-Tetrahydrocannabinol (the major active component of marihuana) administered intravenously to normal human volunteers persists in plasma for more than 3 days (t(1/2) = 56 hours). Its metabolites appear in plasma within 10 minutes after administration and persist along with the precursor compound. Delta(9)-Tetrahydrocannabinol is completely metabolized in man, and the radioactive metabolites are excreted in urine and feces for more than 8 days. 
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