Marginal zone B cells are naturally reactive to collagen type II and initiate the immune response in collagen-induced arthritis

@inproceedings{Prokopec2009MarginalZB,
  title={Marginal zone B cells are naturally reactive to collagen type II and initiate the immune response in collagen-induced arthritis},
  author={Kajsa E Prokopec and Cecilia Carnrot and Kristina R{\aa}sbo and Mikael C I Karlsson and Sandra Kleinau},
  year={2009}
}
B cells are important in collagen-induced arthritis (CIA) and antibodies against type II collagen (CII) are essential for disease development. How and where the autoimmune B cell response is activated in CIA is not fully known. Here we describe where autoreactive B cells are initiated following immunization with CII. Unimmunized mice and mice immunized with ovalbumin (OVA) were used as controls. Surprisingly, we discovered that naïve DBA/1 mice display IgM, but also IgG, positive B cells… CONTINUE READING

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