Marginal vacuoles (fire-flare appearance) in fine needle aspiration smears of thyroid lesions: does it represent diffusing out of thyroid hormones at the base of follicular cells?

@article{Das2006MarginalV,
  title={Marginal vacuoles (fire-flare appearance) in fine needle aspiration smears of thyroid lesions: does it represent diffusing out of thyroid hormones at the base of follicular cells?},
  author={Dilip K Das},
  journal={Diagnostic cytopathology},
  year={2006},
  volume={34 4},
  pages={277-83}
}
Marginal vacuoles (MVs) or fire-flare appearance in May-Grünwald Giemsa stained fine needle aspiration (FNA) smears was initially described as a distinctive feature of thyrotoxic goiter in hyperthyroidism, but was subsequently found in various nontoxic thyroid lesions, both non-neoplastic and neoplastic. Although these MVs have been characterized as dilated endoplasmic reticulum, and manifestation of active pinocytosis/vacuoles containing colloid, their exact nature is not so far resolved. In… CONTINUE READING