Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.

  title={Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.},
  author={Miguel A. Hern{\'a}n and Babette A. Brumback and James M. Robins},
  volume={11 5},
Standard methods for survival analysis, such as the time-dependent Cox model, may produce biased effect estimates when there exist time-dependent confounders that are themselves affected by previous treatment or exposure. Marginal structural models are a new class of causal models the parameters of which are estimated through inverse-probability-of-treatment weighting; these models allow for appropriate adjustment for confounding. We describe the marginal structural Cox proportional hazards… CONTINUE READING
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