Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.

@article{Hernn2000MarginalSM,
  title={Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.},
  author={Miguel A. Hern{\'a}n and Babette A. Brumback and James M. Robins},
  journal={Epidemiology},
  year={2000},
  volume={11 5},
  pages={561-70}
}
Standard methods for survival analysis, such as the time-dependent Cox model, may produce biased effect estimates when there exist time-dependent confounders that are themselves affected by previous treatment or exposure. Marginal structural models are a new class of causal models the parameters of which are estimated through inverse-probability-of-treatment weighting; these models allow for appropriate adjustment for confounding. We describe the marginal structural Cox proportional hazards… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 15 references

Sensitivity analysis for selection bias and unmeasured confounding in missing data and causal inference models

JM Robins, A Rotnitzky, DO Scharfstein
Statistical Methods in Epidemiology : The Environment and Clinical Trials • 1999

Structural nested failure time models

JM Robins
section eds. Survival Analysis • 1998
View 1 Excerpt

A controlled trial of zidovudine in primary human immunodeficiency virus infection

S Kinloch-De Loes, BJ Hirschel, +7 authors L Mathiesen
N Engl J Med • 1995

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