Marek's Disease Virus Infection in the Brain: Virus Replication, Cellular Infiltration, and Major Histocompatibility Complex Antigen Expression

  title={Marek's Disease Virus Infection in the Brain: Virus Replication, Cellular Infiltration, and Major Histocompatibility Complex Antigen Expression},
  author={Isabel M. Gimeno and Richard L. Witter and Henry D. Hunt and L. F. Lee and Sanjay M Reddy and Ulrich Neumann},
  journal={Veterinary Pathology},
  pages={491 - 503}
Marek's disease virus (MDV) infection in the brain was studied chronologically after inoculating 3-week-old chickens of two genetic lines with two strains of serotype 1 MDV representing two pathotypes (v and vv++). Viral replication in the brain was strongly associated with the development of lesions. Three viral antigens (pp38, gB, and meq) were detected in the brain of infected chickens. Marked differences between v and vv++ pathotypes of MDV were identified for level of virus replication… 

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