Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells

@inproceedings{Jiang2013MarchantinMA,
  title={Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells},
  author={Hong Jiang and Jintang Sun and Qi Xu and Ying-xi Liu and Jun Wei and Charles Y. F. Young and Hui-qing Yuan and Hongxiang Lou},
  booktitle={Cell Death and Disease},
  year={2013}
}
We previously reported that marchantin M (Mar) is an active agent to induce apoptosis in human prostate cancer (PCa), but the molecular mechanisms of action remain largely unknown. Here, we demonstrate that Mar potently inhibited chymotrypsin-like and peptidyl-glutamyl peptide-hydrolyzing activities of 20S proteasome both in in vitro and intracellular systems and significantly induced the accumulation of polyubiquitinated proteins in PCa cells. The computational modeling analysis suggested that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…