Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro.

@article{Jensen2012MarchantinAA,
  title={Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitro.},
  author={Sophie Jensen and Sesselja {\'O}marsd{\'o}ttir and Angela Gono Bwalya and Morten Agertoug Nielsen and Deniz Tasdemir and Elin S Olafsdottir},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2012},
  volume={19 13},
  pages={1191-5}
}
In vitro anti-plasmodial activity-guided fractionation of a diethyl ether extract of the liverwort species Marchantia polymorpha, collected in Iceland, led to isolation of the bisbibenzyl ether, marchantin A. The structure of marchantin A (1) was confirmed by NMR and HREIMS. Marchantin A inhibited proliferation of the Plasmodium falciparum strains, NF54 (IC(50)=3.41μM) and K1 (IC(50)=2.02μM) and showed activity against other protozoan species Trypanosoma brucei rhodesiense, T. cruzi and… CONTINUE READING