Marburgviruses: An Update

  title={Marburgviruses: An Update},
  author={Caterina M. Miraglia},
  journal={Laboratory Medicine},
Ebolaviruses have gained much attention recently due to the outbreak from 2014 through 2016. The related marburgviruses also have been responsible for large outbreaks with high case fatality rates. The purpose of this article is to provide the clinical laboratory scientist with a review of the most current developments in marburgvirus research. The PubMed database was reviewed using the keywords "Marburg virus," "Ravn virus," and "marburgviruses," with publication dates from January 1, 2015… 
5 Citations
Recombinant Protein Filovirus Vaccines Protect Cynomolgus Macaques From Ebola, Sudan, and Marburg Viruses
It was demonstrated that combinations of MARV or SUDV with the EBOV vaccine can be formulated yielding bivalent vaccines retaining full efficacy and the recombinant subunit vaccine platform should allow the development of a safe and efficacious multivalent vaccine candidate for protection against Ebola, Marburg and Sudan Virus Disease.
Pan-filovirus one-step reverse transcription-polymerase chain reaction screening assay
A one-step conventional pan-filovirus RT-PCR assay capable of specific amplification of viral RNA of all six primate-pathogenic (human and non-human) filovirus species and resulted in 317 bp long RT- PCR products.
Orthohantavirus is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family Hantaviridae within the order Bunyavirales. Members are called orthohantaviruses or simply
Generalidades de la familia Filoviridae y el virus del Ébola: una actualización de sus implicaciones en la población humana
No existe un tratamiento especifico para the enfermedad, pero actualmente se estan desarrollando vacunas potenciales con efectividad en modelos animales, lo that podria conllevar a un tratsmane eficaz that incremente the supervivencia of los pacientes infectados and a un mejor control epidemiologico.


Immune Response to Marburg Virus Angola Infection in Nonhuman Primates.
MARV Angola displayed the same virulence and disease pathology as EBOV, and appears to cause a more rapid onset and severe outcome of infection than other MARV strains.
Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in Angola
While the marburgviruses exhibit high overall genetic diversity, only 6.8% nucleotide difference was found between the West African Angolan viruses and the majority of East African viruses, suggesting that the virus reservoir species in these regions are not substantially distinct.
Sequencing ebola and marburg viruses genomes using microarrays
Se sequencing‐by‐hybridization (SBH) technique using high density microarrays to identify Ebola and Marburg viruses and it was possible to distinguish between different strains of the Lake Victoria Marburgvirus.
Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques
This study provides a longitudinal examination of clinical disease of aerosol MARV Angola infection in the rhesus macaque model to provide a well-characterized model of disease progression following aerosol exposure.
Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody
It is demonstrated that one of these human monoclonal antibodies, MR191-N, can confer a survival benefit of up to 100% to Marburg or Ravn virus–infected rhesus macaques when treatment is initiated up to 5 days post-inoculation.
Marburg Virus in Fruit Bat, Kenya
BAT collection sites and location of Kitum Cave, Kenya, where Lake Victoria Marburgvirus was detected, and Phylogenetic comparisons demonstrated that the virus was relatively distant from previous isolates from Kenya, similar to viruses isolated from index cases in Europe in 1967.
Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya.
Comparison of nucleotide sequences for portions of the glycoprotein genes of Marburg-Ravn were compared with Marburg reference strains Musoki (MUS) and Popp (POP) to suggest that Ravn is another subtype ofMarburg virus, analogous to the emerging picture of a spectrum of Ebola geographic isolates and subtypes.
The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge
Eritoran protects against the lethality caused by EBOV and the closely related Marburg virus (MARV) in mice and effectively promotes survival of mice of filovirus infection, as 70% and 90% of mice receiving daily eritoran treatment survived lethal E BOV and MARV infections, respectively.
Basic clinical and laboratory features of filoviral hemorrhagic fever.
This compilation will be of value to medical workers responding to epidemics and to investigators attempting to develop animal models of filoviral HF by identifying key unanswered questions and gaps in clinical data that will help guide clinical research in future outbreaks.
Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection
The discovery of two tags at Python Cave from bats marked at Kitaka mine, together with the close genetic linkages evident between viruses detected in geographically distant locations, are consistent with R. aegyptiacus bats existing as a large meta-population with associated virus circulation over broad geographic ranges.