Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women.

@article{Dumond2009MaravirocCI,
  title={Maraviroc concentrates in the cervicovaginal fluid and vaginal tissue of HIV-negative women.},
  author={Julie B Dumond and Kristine B Patterson and Allison L Pecha and Rebecca E. Werner and Emma N. Andrews and Bharat Damle and Randall L. Tressler and Jochen Worsley and Angela Dm Kashuba},
  journal={Journal of acquired immune deficiency syndromes},
  year={2009},
  volume={51 5},
  pages={546-53}
}
OBJECTIVE To compare single- and multiple-dose maraviroc exposures in cervicovaginal fluid (CVF) and vaginal tissue (VT) with blood plasma (BP) and quantify maraviroc protein binding in CVF. DESIGN Open-label pharmacokinetic study. METHODS In 12 HIV-negative women, 7 paired CVF and BP samples were collected over 12 hours after 1 maraviroc dose. Subjects then received maraviroc twice daily for 7 days. After the last dose, subjects underwent CVF and BP sampling as on day 1, with additional… CONTINUE READING

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