Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity.

@article{Pinar2008MaprotilineIW,
  title={Maprotiline induced weight gain in depressive disorder: changes in circulating ghrelin and adiponectin levels and insulin sensitivity.},
  author={Murat Pinar and Murat Gulsun and Ilker Tasci and A. Burak Erdil and Erol Bolu and Cengizhan Açikel and Ali Doruk},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2008},
  volume={32 1},
  pages={135-9}
}
Agents such as clozapine, olanzapine and mirtazapine frequently trigger an increase in body weight. Though the mechanisms have not been thoroughly clarified, recent studies indicate a role for ghrelin in regulation of appetite and weight gain. We investigated the relation of maprotiline induced weight gain to serum ghrelin and adiponectin levels, as well as insulin resistance in lean subjects with depressive disorder. A total of 40 male lean subjects with depressive disorder were treated with… CONTINUE READING