Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies.

@article{FusarPoli2012MappingVT,
  title={Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies.},
  author={Paolo Fusar-Poli and Oliver D. Howes and Andreas Bechdolf and Stefan J. Borgwardt},
  journal={Journal of psychiatry \& neuroscience : JPN},
  year={2012},
  volume={37 3},
  pages={
          170-84
        }
}
BACKGROUND Although early interventions in individuals with bipolar disorder may reduce the associated personal and economic burden, the neurobiologic markers of enhanced risk are unknown. METHODS Neuroimaging studies involving individuals at enhanced genetic risk for bipolar disorder (HR) were included in a systematic review. We then performed a region of interest (ROI) analysis and a whole-brain meta-analysis combined with a formal effect-sizes meta-analysis in a subset of studies… 
View on PubMed
europepmc.org
107 Citations
Highly Influential Citations
7
Background Citations
30
Methods Citations
2
Results Citations
5

Figures and Tables from this paper

107 Citations

Citation Type

Citation Type

Bipolar disorder: Functional neuroimaging markers in relatives
The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies
Individuals at increased risk for development of bipolar disorder display structural alterations similar to people with manifest disease
TLDR
The thinner cortex in help-seeking individuals at risk of bipolar disorder is in line with previous findings in patients with the established disorder and corresponds to the region of the highest effect size in the ENIGMA study of cortical alterations.
Neurobiology of Risk for Bipolar Disorder
TLDR
Although the knowledge on the neurobiology of risk for BD has been inadequate to provide benefits for clinical practice, further studies on structural and functional changes in the brain, neurocognitive functioning, and neurochemical modulation have a potential to reveal biomarkers for risk and resilience for BD.
Prospective longitudinal study of subcortical brain volumes in individuals at high familial risk of mood disorders with or without subsequent onset of depression
A meta-analysis of fMRI studies in healthy relatives of patients with schizophrenia
TLDR
A meta-analysis of whole-brain functional magnetic resonance imaging studies that compared adult healthy relatives of patients with schizophrenia and controls found a general pattern of overactivation across the 21 fMRI studies, which may represent a candidate endophenotype for schizophrenia.
Brain Structural Effects of Psychopharmacological Treatment in Bipolar Disorder
TLDR
The literature to date supports a normalising effect of lithium and mood stabilisers on brain structure in bipolar disorder, which is consistent with the neuroprotective characteristics of these medications identified by preclinical studies.
Amygdala structure and function in paediatric bipolar disorder and high-risk youth: A systematic review of magnetic resonance imaging findings
  • A. Simonetti, K. Saxena, G. Sani
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2021
TLDR
Amygdala hyperactivity to emotional stimuli is the most commonly reported finding in youth with pBP and HR compared to healthy peers (HC), whereas findings from structural MRI studies are inconsistent.
Neuroimaging Markers of Risk, Disease Expression, and Resilience to Bipolar Disorder
  • S. Frangou
  • Psychology, Medicine
    Current Psychiatry Reports
  • 2019
TLDR
Resilience to bipolar disorder is not the reverse of risk but is associated with adaptive brain changes indicative of increased neural reserve, which may open new avenues in preventing and treating bipolar disorder.
Brain changes in early-onset bipolar and unipolar depressive disorders: a systematic review in children and adolescents
TLDR
A systematic literature search of studies between 1980 and September 2013 which reported WM/GM changes in pediatric and adolescent BD/UD, as detected by diffusion tensor imaging and voxel-based analysis was conducted and it is still unclear whether these alterations may be considered as common trait markers or may be used to distinguish BD from UD.
...
...

References

SHOWING 1-10 OF 79 REFERENCES
Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder
Functional neuroimaging studies of bipolar disorder: Examining the wide clinical spectrum in the search for disease endophenotypes
TLDR
Findings from recent studies employing functional neuroimaging to examine functional abnormalities in neural systems underlying core domains of the psychopathology in BP: emotion processing, emotion regulation and executive control, and common comorbid features of BP are reviewed to facilitate future identification of diagnostically-relevant biomarkers of the disorder.
Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder.
TLDR
The meta-analyses revealed robust but regionally nonspecific changes of brain structure in bipolar disorder and revealed individual studies will remain underpowered unless sample size is increased or improvements in phenotypic selection and imaging methods are made to reduce within-study heterogeneity.
Amygdala and Hippocampal Volumes in Relatives of Patients with Bipolar Disorder: A High—Risk Study
  • T. Hajek, E. Gunde, M. Alda
  • Psychology, Medicine
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2009
TLDR
Hippocampal and amygdala volume abnormalities were absent in unaffected and affected relatives of patients with BD and thus did not meet criteria for endophenotype.
The structural neuroimaging of bipolar disorder
TLDR
The most consistent findings include preservation of total cerebral volume with regional grey and white matter structural changes in prefrontal, midline and anterior limbic networks, non-contingent ventriculomegaly and increased rates of white matter hyperintensities, with more pronounced deficits in juveniles suffering from the illness.
Neuroanatomy of vulnerability to psychosis: A voxel-based meta-analysis
Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?
TLDR
Examination of whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls suggests a potential marker for risk for BD and can be considered as a potential neuroprotective marker for the disorder.
Dissociable Brain Structural Changes Associated with Predisposition, Resilience, and Disease Expression in Bipolar Disorder
TLDR
The data suggest that in BD, genetic and phenotype-related influences on brain structure are dissociable; if replicated, these findings may help with early identification of high-risk individuals who are more likely to transition to syndromal states.
Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes.
TLDR
Investigating the relationship between genetic risk and structural variation throughout the entire brain in patients and their unaffected relatives sampled from multiply affected families with schizophrenia or bipolar disorder found the 2 major psychoses show both distinctive and similar patterns of brain structural abnormality related to variable genetic risk.
Neuroanatomical maps of psychosis onset: voxel-wise meta-analysis of antipsychotic-naive VBM studies.
TLDR
Vulnerability to psychosis is associated with consistent GM decreases in prefrontal and temporolimbic areas and neuroanatomical alterations in temporal regions may underlie the clinical onset of psychotic symptoms.
...
...