Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.

Abstract

Colonization of mucosal respiratory surfaces is a prerequisite for the human pathobiont Streptococcus pneumoniae (the pneumococcus) to cause severe invasive infections. The arsenal of pneumococcal adhesins interacts with a multitude of extracellular matrix proteins. A paradigm for pneumococci is their interaction with the adhesive glycoprotein fibronectin… (More)
DOI: 10.1111/mmi.13740

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Cite this paper

@article{Kanwal2017MappingTR, title={Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.}, author={Sajida Kanwal and Inga Jensch and Gottfried Julius Palm and Mark Br{\"o}nstrup and Manfred Rohde and Thomas P Kohler and Daniela Somplatzki and Werner Tegge and Howard F Jenkinson and Sven Hammerschmidt}, journal={Molecular microbiology}, year={2017}, volume={105 6}, pages={839-859} }