Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

@article{Bagci2019MappingTP,
  title={Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms},
  author={H. Bagci and Neera Sriskandarajah and A. Robert and J. Boulais and Islam E. Elkholi and Viviane Tran and Zhen-Yuan Lin and Marie-Pier Thibault and N. Dub{\'e} and D. Faubert and D. Hipfner and A. Gingras and J. C{\^o}t{\'e}},
  journal={Nature Cell Biology},
  year={2019},
  volume={22},
  pages={120-134}
}
Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to effectors. Here, we exploited proximity-dependent biotinylation to systematically define the Rho family proximity interaction network from 28 baits to produce 9,939 high-confidence proximity interactions in two cell lines. Exploiting the nucleotide states of Rho GTPases, we revealed the landscape of interactions with RhoGEFs and… Expand
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