Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy.

@article{Fang2012MappingTP,
  title={Mapping the protein interaction network of the human COP9 signalosome complex using a label-free QTAX strategy.},
  author={Lei Fang and Robyn M. Kaake and Vishal R. Patel and Yingying Yang and Pierre Baldi and Lan Huang},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 5},
  pages={138-47}
}
The COP9 signalosome (CSN) is a multi-subunit protein complex that performs critical roles in controlling diverse cellular and developmental processes. Aberrant regulation of the CSN complex has been shown to lead to tumorigenesis. Despite its biological significance, our current knowledge of the function and regulation of the CSN complex is very limited. To explore CSN biology, we have developed and employed a new version of the tag team-based QTAX strategy (quantitative analysis of tandem… CONTINUE READING
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