Mapping the neural circuit activated by alarm pheromone perception by c-Fos immunohistochemistry

@article{Kiyokawa2005MappingTN,
  title={Mapping the neural circuit activated by alarm pheromone perception by c-Fos immunohistochemistry},
  author={Yasushi Kiyokawa and Takefumi Kikusui and Yukari Takeuchi and Yuji Mori},
  journal={Brain Research},
  year={2005},
  volume={1043},
  pages={145-154}
}
We previously reported that the alarm pheromones released from stressed male rats exaggerated both behavioral and autonomic (stress-induced hyperthermia) responses in recipient rats that were introduced into a novel environment. Subsequent experiments provided evidence that these alarm pheromones could be divided into two functionally different categories based on the site specificity and testosterone dependency of their production. However, the neural mechanisms underlying these behavioral and… Expand
c-Fos expression during the modulation of sexual behavior by an alarm pheromone
TLDR
It is proposed that the alarm pheromone modifies sexual behavior by inducing CRH release that indirectly activates the nucleus paragigantocellularis. Expand
Temporary inactivation of the anterior part of the bed nucleus of the stria terminalis blocks alarm pheromone-induced defensive behavior in rats
TLDR
The data indicate that the aBNST plays an important role in the mediation of the alarm pheromone-induced defensive behavior in rats, and that local microinjections of the GABAA receptor-agonist muscimol modulates alarm phersomone -induced defensive behaviors. Expand
Neural correlates underlying naloxone-induced amelioration of sexual behavior deterioration due to an alarm pheromone
TLDR
It is hypothesized that the alarm pheromone deteriorated sexual behavior by activating the ventrolateral periaqueductal gray-nucleus paragigantocellularis cluster and suppressing the magnocellular part of the paraventricular nucleus of the hypothalamus (PVN) via the opioidergic pathway. Expand
Exposure to an Alarm Pheromone Combined with Footshock Stress Enhances Responsivity of the Medial Amygdala-Hippocampus Circuit
Alarm substances are released under stressful situations and may constitute signals that prevent other members of the group from encountering dangerous situations by producing fear. 2-Heptanone is anExpand
Alarm pheromone that aggravates stress-induced hyperthermia is soluble in water.
TLDR
Water collected from the box containing the alarm pheromone was found to generate a reproduction of all of the responses seen in the animal that had been directly exposed to alarm peromone in the authors' previous studies, which suggest that the alarms phersomone is soluble in water. Expand
Alarm pheromone increases defensive and risk assessment behaviors in male rats
TLDR
The comparison with previous results suggests that the alarm pheromone released from the perianal region of the male rat increases anxiety in recipients, rather than evoking a stereotyped autonomic response. Expand
Removal of the vomeronasal organ blocks the stress-induced hyperthermia response to alarm pheromone in male rats.
TLDR
The results strongly suggest that male rats perceive alarm pheromone with the VNO, and the results of the habituation/dishabituation test and soybean agglutinin binding to the accessory olfactory bulb verified the complete ablation of the vomeronasal organ (VNO) with a functional MOS in the phersomone recipients. Expand
Induction of Fos-immunoreactivity in the rat brain following disinhibition of the dorsomedial hypothalamus
TLDR
Disinhibition of neurons in the DMH in conscious rats results in increases in Fos expression in selected forebrain and brainstem regions that have been implicated in stress-induced physiological changes, anxiety, and experimental fever. Expand
Processing of intraspecific chemical signals in the rodent brain
TLDR
This review is a brief introduction to the processing of intraspecific chemosensory stimuli beyond the secondary projection, focusing on the activity of the relevant amygdala and hypothalamic nuclei, namely the medial amygdala and ventromedial hypothalamus. Expand
The alarm pheromone in male rats as a unique anxiety model: Psychopharmacological evidence using anxiolytics
TLDR
The alarm pheromone-enhanced ASR was not affected by vehicle pretreatment but was dose-dependently attenuated by pretreatment with midazolam, phenelzine, propranolol, clonidine, and CP-154,526-although not buspirone, which may reflect some aspects of the predictive validity of the alarm pothole-induced anxiety in rats as an animal model of human anxiety. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 57 REFERENCES
Alarm pheromone enhances stress-induced hyperthermia in rats
TLDR
It is suggested that an alarm pheromone enhances stress responses of conspecific animals both behaviorally and physiologically, and that these effects are mediated via activation of the accessory olfactory bulb. Expand
Mating and agonistic behavior produce different patterns of Fos immunolabeling in the male Syrian hamster brain
TLDR
Results of this study demonstrate both similarities and differences in brain activation patterns following these two social behaviors and suggest that mating and agonistic behavior activate distinct neural circuits. Expand
Neural Correlates of Cat Odor-Induced Anxiety in Rats: Region-Specific Effects of the Benzodiazepine Midazolam
TLDR
The results indicate that midazolam exerts a region-specific effect on the neural substrates activated by predator odor, with effects in the lateral septum and dorsal premammillary nucleus likely to be of major importance. Expand
Modulatory role of testosterone in alarm pheromone release by male rats
TLDR
The results suggest that the alarm pheromone released from stressed male rats can be classified into at least two categories according to the androgen dependency of their production and/or release. Expand
‘When a rat smells a cat’: the distribution of Fos immunoreactivity in rat brain following exposure to a predatory odor
TLDR
Robust Fos expression in the ventromedial hypothalamus, premamillary nucleus and periaqueductal gray confirms previous suggestions of a role for these areas in predator-induced defensive behavior and draws attention to this subregion as a possible interface between olfactory input and emotional output. Expand
Differential distribution of Fos expression within the male rat preoptic area and hypothalamus in response to physical vs. psychological stress
TLDR
Findings that Fos-ir occurs in several common sites following exposure to REST or IM stress suggest that local neuron populations may comprise a common neural pathway(s) that is activated by intense forms of stress. Expand
Strain differences in Fos expression following airpuff startle in Spontaneously Hypertensive and Wistar Kyoto rats
TLDR
The present results are the first to identify a set of brain regions likely to be responsible for the mediation of the cardiovascular and motor responses associated with the airpuff startle stimulus, and several of the identified areas contain neurotransmitters implicated by prior pharmacological studies. Expand
Alarm pheromones with different functions are released from different regions of the body surface of male rats.
TLDR
The results suggest that the alarm pheromone released from the face modifies behavior and that from the anal area induces autonomic stress responses in recipients. Expand
Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment
TLDR
The data demonstrate that upon whisker stimulation by exploration of a novel, enriched environment, subcortical relay stations in the whisker-to-barrel pathway are able to express elevated levels of c-Fos and in the barrel cortex c- Fos, JunB, Krox-24 and ICER are differentially regulated in the temporal domain. Expand
CRFergic Innervation Of the Paraventricular Nucleus of the Rat Hypothalamus: A Tract‐Tracing Study
TLDR
Many retrogradely labeled CRF neurons were found in the perifornical hypothalamic nucleus (PeF), the dorsolateral hypothalamic area (DA) and the dorsomedial nucleus of the hypothalamus (DMH), which may represent an anatomical substrate underlying the function of the stress‐integrative PVH neurons in the autonomic, behavioral and neuroendocrine regulation during the stress response, including CRF autoregulation. Expand
...
1
2
3
4
5
...