Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.

  title={Mapping the major human T helper epitopes of tetanus toxin. The emerging picture.},
  author={Jeanette C. Reece and H. Mario Geysen and Stuart J Rodda},
  journal={Journal of immunology},
  volume={151 11},
Progress on the mapping of Th epitopes of tetanus toxin (tt) has been slow due to reliance on studies of clones. In this paper, human Th cell epitopes of tt were mapped using proliferation tests on PBMC in response to synthetic peptides. PBMC from nine donors were tested over the entire set of tt homologous overlapping dodecapeptides. The 1304 peptides were initially tested as 66 pools, each containing an average of 20 peptides. PBMC from individual donors responded to as few as 1 and as many… CONTINUE READING
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