Mapping the limits of the human pseudoautosomal region and a candidate sequence for the male-determining gene

@article{Pritchard1987MappingTL,
  title={Mapping the limits of the human pseudoautosomal region and a candidate sequence for the male-determining gene},
  author={Catrin A. Pritchard and Paul J Goodfellow and Peter N. Goodfellow},
  journal={Nature},
  year={1987},
  volume={328},
  pages={273-275}
}
The human Y chromosome is composed of two different parts: a pseudoautosomal region shared with the X chromosome which is responsible for sex chromosome pairing and a Y-specific part that encodes the sex determining gene1. Previously we have shown that the pseudoautosomal gene MIC2 only rarely recombines between the sex chromosomes and, based on the elevated recombination rates in the pseudoautosomal region, we predicted that this gene would lie close to the Y-specific region2. In this report… CONTINUE READING
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