Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique.

@article{Lamprecht2012MappingTI,
  title={Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique.},
  author={Constanze Lamprecht and Notburga Gierlinger and Elena Heister and Barbara Unterauer and Birgit Plochberger and Mario Brameshuber and P. Hinterdorfer and Stefan Hild and Andreas Ebner},
  journal={Journal of physics. Condensed matter : an Institute of Physics journal},
  year={2012},
  volume={24 16},
  pages={
          164206
        }
}
The uptake of carbon nanotubes (CNTs) by mammalian cells and their distribution within cells is being widely studied in recent years due to their increasing use for biomedical purposes. The two main imaging techniques used are confocal fluorescence microscopy and transmission electron microscopy (TEM). The former, however, requires labeling of the CNTs with fluorescent dyes, while the latter is a work-intensive technique that is unsuitable for in situ bio-imaging. Raman spectroscopy, on the… CONTINUE READING

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